the effect of a 12 -week endurance training on il-6, il-10 and nesfatin -1 plasma level of obese male rats

نویسندگان

روح الله حق شناس

استادیار گروه فیزیولوژی ورزش دانشگاه سمنان علی اصغر رواسی

استاد گروه فیزیولوژی ورزش دانشگاه تهران محمدرضا کردی

دانشیار گروه فیزیولوژی ورزش دانشگاه تهران مهدی هدایتی

استادیار دانشگاه علوم پزشکی شهید بهشتی فاطمه شبخیز

چکیده

exercise training has been shown to decrease chronic low- grade systemic inflammation in high- fat diet induced obesity. however, the mechanisms mediating its beneficial effects are not fully understood. therefore, the aim of this study was to investigate the effects of a 12- week endurance training on il-6, il-10 and nesfatin -1 in obese male rats. sixteen male wistar rats (2 months old) were fed a high fat diet for 8 weeks, reaching an average weight of 319 ± 30g. the animals were randomly divided into control (n=8) and 12-week endurance training (t, n=8) groups. training group was given exercise on motor- driven treadmill at 25 to 30 m/min (0% grade), 60 min/day, 5 days/week for 12 weeks, and both groups were given “ad libitum”. the elisa method was used for laboratory analysis of nesfatin-1, il-6 and il-10. the results revealed that the average weight of rats in t group was significantly lower than that of the control group (p=0.001). a significant decrease was also observed in il-6 t group (p=0.04). nesfatin – 1 plasma level increased in t group (p=0.001). despite the fact that il-10 was lower in t group, the difference was not significant. the results of present study showed that long- term endurance training led to an increase in the anti- inflammatory nesfatin -1, and nesfatin- 1 probably plays a role in energy balance, that is independent of the changes of il-10 and il-6 in plasma level.

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عنوان ژورنال:
علوم زیستی ورزشی

جلد ۵، شماره ۴، صفحات ۱۰۹-۱۲۲

کلمات کلیدی
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